Article
DominantMapper: rule-based analysis of SNP data for rapid mapping of dominant diseases in related nuclear families.
Human mutation - 1 Dec 2011
Carr Ian M, Johnson Colin A, Markham Alex F, Toomes Carmel, Bonthron David T, Sheridan Eamonn G
Abstract excerpt
With the advent of cheap rapid methods for whole-genome SNP genotyping and the completion of the Human Genome Project, mapping disease loci has become primarily a bioinformatic rather than a laboratory problem. Here, we describe DominantMapper, a computer program that implements a rule-based analysis algorithm for the detection of dominant disease loci in either a small number of nuclear families or a single...
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