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Article

Structural basis for the broad specificity to host-cell ligands by the pathogenic fungus Candida albicans.

Proceedings of the National Academy of Sciences of the United States of America - 20 Sept 2011

Salgado Paula S, Yan Robert, Taylor Jonathan D, Burchell Lynn, Jones Rhian, Hoyer Lois L, Matthews Steve J, Simpson Peter J, Cota Ernesto

Abstract excerpt

Candida albicans is the most prevalent fungal pathogen in humans and a major source of life-threatening nosocomial infections. The Als (agglutinin-like sequence) glycoproteins are an important virulence factor for this fungus and have been associated with binding of host-cell surface proteins and small peptides of random sequence, the formation of biofilms and amyloid fibers. High-resolution structures of...

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Identifiers

PMID: 21896717
DOI: 10.1073/pnas.1103496108
PMCID: PMC3179088

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