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Article

Structural Hot Spots Determine Functional Diversity of the Candida glabrata Epithelial Adhesin Family.

The Journal of biological chemistry - 7 Aug 2015

Diderrich Rike, Kock Michael, Maestre-Reyna Manuel, Keller Petra, Steuber Holger, Rupp Steffen, Essen Lars-Oliver, Mösch Hans-Ulrich

Abstract excerpt

For host colonization, the human fungal pathogen Candida glabrata is known to utilize a large family of highly related surface-exposed cell wall proteins, the lectin-like epithelial adhesins (Epas). To reveal the structure-function relationships within the entire Epa family, we have performed a large scale functional analysis of the adhesion (A) domains of 17 Epa paralogs in combination with three-dimensional...

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Identifiers

PMID: 26105055
DOI: 10.1074/jbc.M115.655654
PMCID: PMC4528126

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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