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Article

Establishment of recombinant hybrid-IgG/IgA immunoglobulin specific for Shiga toxin.

Scandinavian journal of immunology - 1 Dec 2011

Tobisawa Y, Maruyama T, Tanikawa T, Nakanishi K, Kurohane K, Imai Y

Abstract excerpt

Shiga toxin 1 produced by enterohaemorrhagic Escherichia coli is an AB(5) toxin that is involved in the life-threatening haemolytic-uraemic syndrome. The B subunits (Stx1B) are cell-binding subunits. We previously established mouse hybridoma cell line producing IgA and IgG monoclonal antibodies (mAbs) against Stx1B. Here, we cloned cDNAs encoding each of the heavy, light and joining (J) chains from the hybridoma...

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Identifiers

PMID: 21883352
DOI: 10.1111/j.1365-3083.2011.02617.x

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