Article
Beta2-adrenergic receptor polymorphisms as a determinant of preferential bronchodilator responses to β2-agonist and anticholinergic agents in Japanese patients with chronic obstructive pulmonary disease.
Pharmacogenetics and genomics - 1 Nov 2011
Konno Satoshi, Makita Hironi, Hasegawa Masaru, Nasuhara Yasuyuki, Nagai Katsura, Betsuyaku Tomoko, Hizawa Nobuyuki, Nishimura Masaharu
Abstract excerpt
BACKGROUND: Previous studies have shown that polymorphisms in the β2-adrenergic receptor gene (ADRB2) may influence bronchodilator response (BDR) to both β2-agonists and anticholinergics, possibly by intracellular cross-talk, but in opposite ways, in the Japanese population. We hypothesized that the preferential response to either class of bronchodilators might be determined by ADRB2 polymorphisms in patients...
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