The yeast KRE5 gene encodes a probable endoplasmic reticulum protein required for (1----6)-beta-D-glucan synthesis and normal cell growth.

doi:10.1128/mcb.10.6.3013-3019.1990

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Article

The yeast KRE5 gene encodes a probable endoplasmic reticulum protein required for (1----6)-beta-D-glucan synthesis and normal cell growth.

Molecular and cellular biology - 1 Jun 1990

Meaden P, Hill K, Wagner J, Slipetz D, Sommer S S, Bussey H

Abstract excerpt

Yeast kre mutants define a pathway of cell wall (1----6)-beta-D-glucan synthesis, and mutants in genes KRE5 and KRE6 appear to interact early in such a pathway. We have cloned KRE5, and the sequence predicts the product to be a large, hydrophilic, secretory glycoprotein which contains the COOH-terminal endoplasmic reticulum retention signal, HDEL. Deletion of the KRE5 gene resulted in cells with aberrant...

Topics

Amino Acid Sequence
Base Sequence
Cell Wall
Chromosome Deletion
Cloning, Molecular
DNA, Fungal
Endoplasmic Reticulum
Escherichia coli
Fungal Proteins
Genes, Fungal
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glucans

Glycoproteins

Molecular Sequence Data

Mutation

Plasmids

Restriction Mapping

Saccharomyces cerevisiae

Source

Open in PubMed Open full text

Identifiers

PMID: 2188106
DOI: 10.1128/mcb.10.6.3013-3019.1990
PMCID: PMC360665

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2188106-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The yeast KRE5 gene encodes a probable endoplasmic reticulum protein required for (1----6)-beta-D-glucan synthesis and normal cell growth.PMID 2188106Read ↗

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