Article
Neuropilin-2 expression in papillary thyroid carcinoma: correlation with VEGF-D expression, lymph node metastasis, and VEGF-D-induced aggressive cancer cell phenotype.
The Journal of clinical endocrinology and metabolism - 1 Nov 2011
Yasuoka Hironao, Kodama Rieko, Hirokawa Mitsuyoshi, Takamura Yuuki, Miyauchi Akira, Inagaki Michiya, Sanke Tokio, Nakamura Yasushi
Abstract excerpt
CONTEXT: Neuropilin-2 (Nrp2) is a coreceptor for vascular endothelial growth factor-D (VEGF-D) that is expressed on the surface of endothelial cells. Recently, Nrp2 was shown to play a role in lymph node metastasis and promotion of cancer cell migration. VEGF-D also promotes lymphangiogenesis, which in turn promotes tumor metastasis. OBJECTIVE: The aim was to study the role of neuropilin-2 in lymph node...
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