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Article

Functional interaction of VEGF‐C and VEGF‐D with neuropilin receptors

30 Jun 2006

Abstract excerpt

Lymphatic vascular development is regulated by vascular endothelial growth factor receptor-3 (VEGFR-3), which is activated by its ligands VEGF-C and VEGF-D. Neuropilin-2 (NP2), known to be involved in neuronal development, has also been implicated to play a role in lymphangiogenesis. We aimed to elucidate the mechanism by which NP2 is involved in lymphatic endothelial cell signaling. By in vitro binding studies...

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PMID: 16816121
DOI: 10.1096/fj.05-5646com

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