Article
Optimized turmeric extract reduces β-Amyloid and phosphorylated Tau protein burden in Alzheimer's transgenic mice.
Current Alzheimer research - 1 May 2012
Shytle R Douglas, Tan Jun, Bickford Paula C, Rezai-Zadeh Kavon, Hou L, Zeng Jin, Sanberg Paul R, Sanberg Cyndy D, Alberte Randall S, Fink Ryan C, Roschek Bill
Abstract excerpt
In a previous in vitro study, the standardized turmeric extract, HSS-888, showed strong inhibition of Aβ aggregation and secretion in vitro, indicating that HSS-888 might be therapeutically important. Therefore, in the present study, HSS-888 was evaluated in vivo using transgenic 'Alzheimer' mice (Tg2576) over-expressing Aβ protein. Following a six-month prevention period where mice received extract HSS-888...
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