Article
Harmaline-resistant mutant of Methanothermobacter thermautotrophicus with a lesion in Na(+)/H(+) antiport.
General physiology and biophysics - 1 Jan 2011
Vidová Monika, Bobáľová Janette, Smigáň Peter
Abstract excerpt
A spontaneous mutant of Methanothermobacter thermautotrophicus resistant to the Na(+)/H(+) antiporter inhibitor harmaline was isolated. The Na(+)/H(+) exchange activity in the mutant cells was remarkably decreased in comparison with wild-type cells. Na(+)/H(+) antiport activity of wild-type cells grown in the high Na(+) concentration (125 mmol/l) was significantly increased as compared to the cells grown under...
Topics
- Adenosine Triphosphate
- Drug Resistance
- Gene Expression Regulation, Archaeal
- Harmaline
- Methane
- Methanobacteriaceae
- Mutation
- Potassium
- Salicylanilides
- Sodium-Hydrogen Exchangers