Article
Accumulation of beneficial mutations in one dimension.
Physical review. E, Statistical, nonlinear, and soft matter physics - 1 Jul 2011
Otwinowski Jakub, Boettcher Stefan
Abstract excerpt
When beneficial mutations are relatively common, competition between multiple unfixed mutations can reduce the rate of fixation in well-mixed asexual populations. We introduce a one-dimensional model with a steady accumulation of beneficial mutations. We find a transition between periodic selection and multiple-mutation regimes. In the multiple-mutation regime, the increase of fitness along the lattice bears a...
Topics
- Algorithms
- Animals
- DNA Mutational Analysis
- Evolution, Molecular
- Genetics
- Genetics, Population
- Humans
- Models, Genetic
- Models, Statistical
- Mutation
- Time Factors