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Article

Shiga toxin 2 overexpression in Escherichia coli O157:H7 strains associated with severe human disease.

Microbial pathogenesis - 1 Dec 2011

Neupane Mahesh, Abu-Ali Galeb S, Mitra Avishek, Lacher David W, Manning Shannon D, Riordan James T

Abstract excerpt

Variation in disease severity among Escherichia coli O157:H7 infections may result from differential expression of Shiga toxin 2 (Stx2). Eleven strains belonging to four prominent phylogenetic clades, including clade 8 strains representative of the 2006 U.S. spinach outbreak, were examined for stx2 expression by real-time PCR and western blot analysis. Clade 8 strains were shown to overexpress stx2 basally, and...

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Identifiers

PMID: 21864671
DOI: 10.1016/j.micpath.2011.07.009
PMCID: PMC3205445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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