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Article

The antioxidant HDL-associated paraoxonase-1 (PON1) attenuates diabetes development and stimulates β-cell insulin release.

Atherosclerosis - 1 Dec 2011

Koren-Gluzer Marie, Aviram Michael, Meilin Edna, Hayek Tony

Abstract excerpt

OBJECTIVE: To analyze the direct effects of paraoxonase-1 (PON1) on diabetes development and on β-cell insulin release. METHODS AND RESULTS: Injection of rePON1 to mice, prior to STZ-induced diabetes, resulted in reduced incidence of diabetes, as well as, in higher serum insulin levels. Incubation of β-cells with PON1 also dose-dependently increased insulin secretion and its cellular content. PON1 increased cell...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21862013
DOI: 10.1016/j.atherosclerosis.2011.07.119

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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