Article
Differential innate immune responses to low or high dose oral SIV challenge in Rhesus macaques.
Current HIV research - 1 Jul 2011
Durudas Andre, Chen Hui-Ling, Gasper Melanie A, Sundaravaradan Vasudha, Milush Jeffrey M, Silvestri Guido, Johnson Welkin, Giavedoni Luis D, Sodora Donald L
Abstract excerpt
Mucosal transmission of HIV predominately occurs during sexual intercourse or breast-feeding and generally results in a successful infection from just one or few founder virions. Here we assessed the impact of viral inoculum size on both viral and immune events within two groups of Rhesus macaques that were non-traumatically, orally inoculated with either multiple low (1000 to 4000 TCID(50)) or high (100,000...
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