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Article

Expression of PROKR1 and PROKR2 in human enteric neural precursor cells and identification of sequence variants suggest a role in HSCR.

PloS one - 1 Jan 2011

Ruiz-Ferrer Macarena, Torroglosa Ana, Núñez-Torres Rocío, de Agustín Juan Carlos, Antiñolo Guillermo, Borrego Salud

Abstract excerpt

BACKGROUND: The enteric nervous system (ENS) is entirely derived from neural crest and its normal development is regulated by specific molecular pathways. Failure in complete ENS formation results in aganglionic gut conditions such as Hirschsprung's disease (HSCR). Recently, PROKR1 expression has been demonstrated in mouse enteric neural crest derived cells and Prok-1 was shown to work coordinately with GDNF in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21858136
DOI: 10.1371/journal.pone.0023475
PMCID: PMC3155560

Genes

PROKR1
PROKR2
GDNF
PROK1
RET
PROK2

Provenance

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