Article
Haplo2Ped: a tool using haplotypes as markers for linkage analysis.
BMC bioinformatics - 22 Aug 2011
Cheng Feng, Zhang Xianglong, Zhang Yinan, Li Chaohua, Zeng Changqing
Abstract excerpt
BACKGROUND: Generally, SNPs are abundant in the genome; however, they display low power in linkage analysis because of their limited heterozygosity. Haplotype markers, on the other hand, which are composed of many SNPs, greatly increase heterozygosity and have superiority in linkage statistics. RESULTS: Here we developed Haplo2Ped to automatically transform SNP data into haplotype markers and then to compute the...
Topics
- Disease
- Genetic Linkage
- Genome-Wide Association Study
- Haplotypes
- Humans
- Pedigree
- Polymorphism, Single Nucleotide
- Retinitis Pigmentosa
- Software