Article
Growth hormone/IGF-I axis and growth hormone receptor mutations in idiopathic short stature.
Hormone research in paediatrics - 1 Jan 2011
El Kholy M, Mella P, Rashad M, Buzi F, Meazza C, Zahra S, Elsedfy H H
Abstract excerpt
BACKGROUND/AIMS: It was hypothesized that some children with idiopathic short stature (ISS) may have partial insensitivity to growth hormone (GH). In this study analysis of the GH/IGF-I axis as well as GH receptor (GHR) gene was done in children with ISS to determine the possible underlying factor(s) to their short stature. METHODS: Forty-eight patients with a diagnosis of ISS were studied; 33 boys and 15 girls...
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