Article
Common variants at the promoter region of the APOM confer a risk of rheumatoid arthritis.
Experimental & molecular medicine - 30 Nov 2011
Hu Hae Jin, Jin Eun Heui, Yim Seon Hee, Yang So Young, Jung Seung Hyun, Shin Seung Hun, Kim Wan Uk, Shim Seung Cheol, Kim Tai Gyu, Chung Yeun Jun
Abstract excerpt
Although the genetic component in the etiology of rheumatoid arthritis (RA) has been consistently suggested, many novel genetic loci remain to uncover. To identify RA risk loci, we performed a genome-wide association study (GWAS) with 100 RA cases and 600 controls using Affymetrix SNP array 5.0. The candidate risk locus (APOM gene) was re-sequenced to discover novel promoter and coding variants in a group of the...
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