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Article

Coordinate control of the locus of enterocyte effacement and enterohemolysin genes by multiple common virulence regulators in enterohemorrhagic Escherichia coli.

Infection and immunity - 1 Nov 2011

Iyoda Sunao, Honda Naoko, Saitoh Takehito, Shimuta Ken, Terajima Jun, Watanabe Haruo, Ohnishi Makoto

Abstract excerpt

The locus of enterocyte effacement (LEE) pathogenicity island is required for the intimate adhesion of enterohemorrhagic Escherichia coli (EHEC) to the intestinal epithelial cells. GrlR and GrlA are LEE-encoded negative and positive regulators, respectively. The interaction of these two regulators is important for controlling the transcription of LEE genes through Ler, a LEE-encoded central activator for the LEE....

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Identifiers

PMID: 21844237
DOI: 10.1128/IAI.05023-11
PMCID: PMC3257950

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