Article
Age-related decline in stress responses of human myocardium may not be explained by changes in mtDNA.
Mechanisms of ageing and development - 1 Jan 2000
Miller Francis, Nagley Phillip, Mariani Justin A, Ou Ruchong, Liu Vincent W S, Zhang Chunfang, Linnane Anthony W, Pepe Salvatore, Rosenfeldt Franklin
Abstract excerpt
Elderly patients undergoing cardiac surgery are more likely to suffer postoperative heart failure than younger patients. This phenomenon is mirrored by an age-related loss of mitochondrial function and by an in vitro loss of myocardial contractile force following a stress. To examine the possibility that loss of mtDNA integrity may be responsible, we quantified representative age-associated mtDNA mutations...
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