Article
Influence of adrenomedullin 2/intermedin gene polymorphism on blood pressure, renal function and silent cerebrovascular lesions in Japanese: the Ohasama study.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Dec 2011
Hirose Takuo, Totsune Kazuhito, Nakashige Yukiko, Metoki Hirohito, Kikuya Masahiro, Ohkubo Takayoshi, Hara Azusa, Satoh Michihiro, Inoue Ryusuke, Asayama Kei, Kondo Takeo, Kamide Kei, Katsuya Tomohiro, Ogihara Toshio, Izumi Shin-Ichi, Rakugi Hiromi, Takahashi Kazuhiro, Imai Yutaka
Abstract excerpt
Adrenomedullin 2/intermedin (AM2/IMD) is a novel vasodilator peptide with various effects on the renal function and cardiovascular system. An exonic insertion (I)/deletion (D) polymorphism (rs3840963) may influence generation of AM2/IMD-53, due to its location within the N-terminal sequence. We investigated the association of this polymorphism with blood pressure, renal function and the risk of silent...
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