Article
The 23K variant of the R23K polymorphism in the glucocorticoid receptor gene protects against postnatal growth failure and insulin resistance after preterm birth.
The Journal of clinical endocrinology and metabolism - 1 Dec 2007
Finken Martijn J J, Meulenbelt Ingrid, Dekker Friedo W, Frölich Marijke, Romijn Johannes A, Slagboom P Eline, Wit Jan M
Abstract excerpt
CONTEXT: Preterm birth is associated with postnatal growth failure, abdominal fat accumulation, insulin resistance, and hypertension, resembling increased glucocorticoid bioactivity. OBJECTIVE: We tested the effects of the R23K and N363S polymorphisms in the glucocorticoid receptor gene, associated with decreased and increased sensitivity to cortisol, respectively, on linear growth and the adult metabolic profile...
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