TGFBR3 polymorphisms and its haplotypes associated with chronic hepatitis B virus infection and age of hepatocellular carcinoma occurrence.

doi:10.1159/000327559

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Article

TGFBR3 polymorphisms and its haplotypes associated with chronic hepatitis B virus infection and age of hepatocellular carcinoma occurrence.

Digestive diseases (Basel, Switzerland) - 1 Jan 2011

Kim Jeong-Hyun, Yu Su Jong, Park Byung-Lae, Cheong Hyun Sub, Pasaje Charisse Flerida A, Bae Joon Seol, Lee Hyo-Suk, Shin Hyoung Doo, Kim Yoon Jun

Abstract excerpt

OBJECTIVE: Hepatocellular carcinoma (HCC) is one of the most common cancers and is mainly caused by viral infections including hepatitis B virus (HBV). Recently, the decreased expression level of the transforming growth factor, beta receptor III (TGFBR3) gene, has been implicated in HCC and other human cancers. This study investigated whether TGFBR3 polymorphisms might be associated with HBV clearance and HCC...

Topics

Adult
Aging
Carcinoma, Hepatocellular
Female
Genetic Predisposition to Disease
Haplotypes
Hepatitis B virus
Hepatitis B, Chronic
Humans
Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Physical Chromosome Mapping

Polymorphism, Single Nucleotide

Proteoglycans

Receptors, Transforming Growth Factor beta

Republic of Korea

Source

Open in PubMed

Identifiers

PMID: 21829018
DOI: 10.1159/000327559

Genes

TGFBR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21829018-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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