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Article

Genetic interactions in the adrenergic system genes: analysis of antipsychotic-induced weight gain.

Human psychopharmacology - 1 Aug 2011

De Luca Vincenzo, Souza Renan P, Viggiano Emanuela, Sickert Laertes, Teo Celine, Zai Clement, Tiwari Arun K, Müller Daniel J, Lieberman Jeffery A, Volavka Jan, Meltzer Herbert Y, Kennedy James L

Abstract excerpt

UNLABELLED: Atypical antipsychotics (AP) have high affinity for many neurotransmitter receptors. Among these receptors, APs are antagonist at α-adrenergic and β-adrenergic receptors, and this pharmacological property has been postulated to be involved in the mechanism of action of these drugs with respect to both clinical response and adverse effects. OBJECTIVE: We tested the hypotheses that AP-induced weight...

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Topics

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Share to Antipsychotic Agents
Share to Catechol O-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopamine beta-Hydroxylase

Share to Monoamine Oxidase

Share to Polymorphism, Genetic

Share to Receptors, Adrenergic

Share to Receptors, Adrenergic, alpha-2

Share to Weight Gain

Source

Identifiers

PMID: 21823169
DOI: 10.1002/hup.1219

Genes

ADRB3
COMT
DBH
MAOA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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