Germline mutations in RAD51D confer susceptibility to ovarian cancer.

doi:10.1038/ng.893

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Article

Germline mutations in RAD51D confer susceptibility to ovarian cancer.

Nature genetics - 7 Aug 2011

Loveday Chey, Turnbull Clare, Ramsay Emma, Hughes Deborah, Ruark Elise, Frankum Jessica R, Bowden Georgina, Kalmyrzaev Bolot, Warren-Perry Margaret, Snape Katie, Adlard Julian W, Barwell Julian, Berg Jonathan, Brady Angela F, Brewer Carole, Brice Glen, Chapman Cyril, Cook Jackie, Davidson Rosemarie, Donaldson Alan, Douglas Fiona, Greenhalgh Lynn, Henderson Alex, Izatt Louise, Kumar Ajith, Lalloo Fiona, Miedzybrodzka Zosia, Morrison Patrick J, Paterson Joan, Porteous Mary, Rogers Mark T, Shanley Susan, Walker Lisa, Eccles Diana, Evans D Gareth, Renwick Anthony, Seal Sheila, Lord Christopher J, Ashworth Alan, Reis-Filho Jorge S, Antoniou Antonis C, Rahman Nazneen

Abstract excerpt

Recently, RAD51C mutations were identified in families with breast and ovarian cancer. This observation prompted us to investigate the role of RAD51D in cancer susceptibility. We identified eight inactivating RAD51D mutations in unrelated individuals from 911 breast-ovarian cancer families compared with one inactivating mutation identified in 1,060 controls (P = 0.01). The association found here was principally...

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PMID: 21822267
DOI: 10.1038/ng.893
PMCID: PMC4845885

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