Article
B-transferase with a Pro234Ser substitution acquires AB-transferase activity.
Bioscience, biotechnology, and biochemistry - 1 Jan 2011
Nishida Chiyomi, Tomita Takeo, Nishiyama Makoto, Suzuki Ryuyo, Hara Mutsuko, Itoh Yukio, Ogawa Hideoki, Okumura Ko, Nishiyama Chiharu
Abstract excerpt
A/B-Transferase is a glycosyltransferase that transfers a sugar substrate onto H-antigen, which is responsible for the synthesis of glycoprotein- and glycolipid-conjugates termed A/B-antigens. One polymorphism that causes the Pro234Ser substitution in B-transferase was recently found in a genotyping study, and might be cis-AB. In the present study, we analyzed the phenotypes arising from the enzymatic specificity...
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