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Article

Construction of multidrug-sensitive yeast with high sporulation efficiency.

Bioscience, biotechnology, and biochemistry - 1 Jan 2011

Chinen Takumi, Ota Yu, Nagumo Yoko, Masumoto Hiroshi, Usui Takeo

Abstract excerpt

Budding yeast is often used in chemical genetics for screening, target identification, and compound verification, but its high-level drug resistance has made the analysis of compounds difficult. Here we report the construction of 12geneΔ0HSR, a strain that lacks eight efflux pumps located on the plasma membrane and four transcription factors involved in expression of efflux pumps, and contains the RME1(ins-308A)...

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PMID: 21821930
DOI: 10.1271/bbb.110311

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