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Article

Analysis of MEFV exon methylation and expression patterns in familial Mediterranean fever

7 Aug 2011

Abstract excerpt

BACKGROUND: MEFV mutations and decreased expression level of the gene are related to FMF pathology. DNA methylation at CpG islands is a well-known mechanism for transcriptional silencing. MEFV has a CpG island, spanning a part of the first intron and the whole of the second exon of the gene covering 998 bp region. Here, we tested the hypothesis that the MEFV transcript level in FMF patients correlates with its...

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PMID: 21819621
DOI: 10.1186/1471-2350-12-105

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