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Article

Progranulin deficiency decreases gross neural connectivity but enhances transmission at individual synapses.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Aug 2011

Tapia Lucia, Milnerwood Austen, Guo Aobo, Mills Fergil, Yoshida Eileen, Vasuta Cristina, Mackenzie Ian R, Raymond Lynn, Cynader Max, Jia William, Bamji Shernaz X

Abstract excerpt

Frontotemporal dementia (FTD) has been linked to mutations in the progranulin gene (GRN) that lead to progranulin (PGRN) haploinsufficiency. Thus far, our understanding of the effects of PGRN depletion in the brain has been derived from investigation of gross pathology, and more detailed analyses...

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Source

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Identifiers

PMID: 21813674
DOI: 10.1523/JNEUROSCI.6244-10.2011
PMCID: PMC6623368

Genes

GRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21813674-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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