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Article

Defect in tyrosine kinase activity of the insulin receptor from a patient with insulin resistance and acanthosis nigricans.

The Journal of clinical endocrinology and metabolism - 1 Apr 1990

Yamamoto R, Shiba T, Tobe K, Shibasaki Y, Koshio O, Izumi T, Odawara M, Mikami Y, Matsuura N, Akanuma Y

Abstract excerpt

We report here a defect in tyrosine kinase activity of the insulin receptor from an insulin-resistant patient with acanthosis nigricans using cultured Ebstein-Barr virus (EBV)-transformed B-lymphocytes. As judged by affinity labeling and immunoblotting, the alpha- and beta-subunits of insulin receptors from the patient's lymphocytes exhibited the same mol wt as those from control subjects. Lectin-purified...

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Identifiers

PMID: 2180980
DOI: 10.1210/jcem-70-4-869

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Defect in tyrosine kinase activity of the insulin receptor from a patient with insulin resistance and acanthosis nigricans.PMID 2180980Read ↗

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Two naturally occurring mutations in the kinase domain of insulin receptor accelerate degradation of the insulin receptor and impair the kinase activity.Semantic proximity Read ↗

Human diabetes associated with defects in nuclear regulatory proteins for the insulin receptor gene.Semantic proximity Read ↗

Reduced mRNA and a nonsense mutation in the insulin-receptor gene produce heritable severe insulin resistance.Semantic proximity Read ↗

Functional properties of a heterozygous mutation (Arg1174-->Gln) in the tyrosine kinase domain of the insulin receptor from a type A insulin resistant patient.Semantic proximity Read ↗

The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth.Semantic proximity Read ↗

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Insulin-receptor autophosphorylation and kinase activity are constitutively increased in fibroblasts cultured from a patient with heritable insulin-resistance.Semantic proximity Read ↗

Deletion of 3 basepairs resulting in the loss of lysine-121 in the insulin receptor alpha-subunit in a patient with leprechaunism: binding, phosphorylation, and biological activity.Semantic proximity Read ↗

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