Defect in tyrosine kinase activity of the insulin receptor from a patient with insulin resistance and acanthosis nigricans.

doi:10.1210/jcem-70-4-869

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Article

Defect in tyrosine kinase activity of the insulin receptor from a patient with insulin resistance and acanthosis nigricans.

The Journal of clinical endocrinology and metabolism - 1 Apr 1990

Yamamoto R, Shiba T, Tobe K, Shibasaki Y, Koshio O, Izumi T, Odawara M, Mikami Y, Matsuura N, Akanuma Y

Abstract excerpt

We report here a defect in tyrosine kinase activity of the insulin receptor from an insulin-resistant patient with acanthosis nigricans using cultured Ebstein-Barr virus (EBV)-transformed B-lymphocytes. As judged by affinity labeling and immunoblotting, the alpha- and beta-subunits of insulin receptors from the patient's lymphocytes exhibited the same mol wt as those from control subjects. Lectin-purified...

Topics

Acanthosis Nigricans
Adenosine Triphosphate
Adolescent
Alleles
B-Lymphocytes
Binding Sites
Cell Transformation, Viral
Cloning, Molecular
DNA
Glycine
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Insulin

Insulin Resistance

Male

Mutation

Peptide Mapping

Phosphorylation

Protein-Tyrosine Kinases

Source

Open in PubMed

Identifiers

PMID: 2180980
DOI: 10.1210/jcem-70-4-869

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2180980-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Defect in tyrosine kinase activity of the insulin receptor from a patient with insulin resistance and acanthosis nigricans.PMID 2180980Read ↗

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