Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A mutation (Trp1193-->Leu1193) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistance.

Diabetologia - 1 May 1993

Iwanishi M, Haruta T, Takata Y, Ishibashi O, Sasaoka T, Egawa K, Imamura T, Naitou K, Itazu T, Kobayashi M

Abstract excerpt

We evaluated a 35-year-old diabetic male patient with type A insulin resistance, showing acanthosis nigricans. Insulin binding to the patient's Epstein-Barr-virus transformed lymphocytes was mildly reduced. The maximal insulin-stimulated autophosphorylation of the insulin receptor from the patient's transformed lymphocytes was decreased to 45% of that from the control subjects. On examination, the biological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Amino Acid Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Base Sequence

Share to Cell Division

Share to Cells, Cultured

Share to Fibroblasts

Source

Identifiers

PMID: 8390949
DOI: 10.1007/BF00402277

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A mutation (Trp1193-->Leu1193) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistance.PMID 8390949Read ↗

A glycine-1008 to valine mutation in the insulin receptor in a woman with type A insulin resistance.Semantic proximity Read ↗

A mutation in the tyrosine kinase domain of the insulin receptor associated with insulin resistance in an obese woman.Semantic proximity Read ↗

Two naturally occurring mutations in the kinase domain of insulin receptor accelerate degradation of the insulin receptor and impair the kinase activity.Semantic proximity Read ↗

Functional properties of a heterozygous mutation (Arg1174-->Gln) in the tyrosine kinase domain of the insulin receptor from a type A insulin resistant patient.Semantic proximity Read ↗

A naturally occurring mutation of insulin receptor alanine 1134 impairs tyrosine kinase function and is associated with dominantly inherited insulin resistance.Semantic proximity Read ↗

Insulin resistance and diabetes due to different mutations in the tyrosine kinase domain of both insulin receptor gene alleles.Semantic proximity Read ↗

Mutations in the insulin receptor gene in patients with genetic syndromes of insulin resistance and acanthosis nigricans.Semantic proximity Read ↗

Functional properties of a naturally occurring Trp1200----Ser1200 mutation of the insulin receptor.Semantic proximity Read ↗

Homozygosity for a new mutation (Ile119-->Met) in the insulin receptor gene in five sibs with familial insulin resistance.Semantic proximity Read ↗

Defect in tyrosine kinase activity of the insulin receptor from a patient with insulin resistance and acanthosis nigricans.Semantic proximity Read ↗

Substitution of Leu for Pro-193 in the insulin receptor in a patient with a genetic form of severe insulin resistance.Semantic proximity Read ↗

Molecular characterization of a novel p.R118C mutation in the insulin receptor gene from patients with severe insulin resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.