A mutation (Trp1193-->Leu1193) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistance.

doi:10.1007/BF00402277

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Article

A mutation (Trp1193-->Leu1193) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistance.

Diabetologia - 1 May 1993

Iwanishi M, Haruta T, Takata Y, Ishibashi O, Sasaoka T, Egawa K, Imamura T, Naitou K, Itazu T, Kobayashi M

Abstract excerpt

We evaluated a 35-year-old diabetic male patient with type A insulin resistance, showing acanthosis nigricans. Insulin binding to the patient's Epstein-Barr-virus transformed lymphocytes was mildly reduced. The maximal insulin-stimulated autophosphorylation of the insulin receptor from the patien...

Topics

Adult
Alleles
Amino Acid Sequence
Aminoisobutyric Acids
Base Sequence
Biological Transport
Blood Glucose
Cell Division
Cell Line, Transformed
Cells, Cultured
Consanguinity
DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Exons

Female

Fibroblasts

Herpesvirus 4, Human

Humans

Insulin

Source

Open in PubMed

Identifiers

PMID: 8390949
DOI: 10.1007/BF00402277

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8390949-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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