Article
Association between osteopontin promoter variants and diastolic dysfunction in hypertensive heart in the Japanese population.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Oct 2011
Nakayama Hiroyuki, Nagai Hiromi, Matsumoto Kyotaka, Oguro Ryosuke, Sugimoto Ken, Kamide Kei, Ohishi Mitsuru, Katsuya Tomohiro, Okamoto Hiroshi, Maeda Makiko, Komamura Kazuo, Azuma Junichi, Rakugi Hiromi, Fujio Yasushi
Abstract excerpt
Heart failure with preserved ejection fraction is recently highlighted as a major health problem, and diastolic dysfunction associated with hypertension has a dominant role in the development of heart failure with preserved ejection fraction. Osteopontin (OPN) is a secreted phosphoprotein, which mediates fibrosis. In animal models, OPN is upregulated in response to pressure overload and is thought to be involved...
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