Article
Significant association of XPD Asp312Asn polymorphism with breast cancer in Taiwanese patients.
The Chinese journal of physiology - 30 Apr 2010
Wang Hwei-Chung, Liu Chiu-Shong, Wang Chung-Hsing, Tsai Ru-Yin, Tsai Chia-Wen, Wang Rou-Fen, Chang Chao-Hsiang, Chen Yueh-Sheng, Chiu Chang-Fang, Bau Da-Tian, Huang Chih-Yang
Abstract excerpt
The DNA repair gene XPD, an important caretaker of the overall genome stability, is thought to play a major role in the development of human malignancy. Polymorphic variants of XPD, at Asp312Asn (rs1799793), Lys751Gln (rs13181), and promoter C-114G (rs3810366), were chosen to be studied of their association with breast cancer susceptibility in a central Taiwanese population. In this hospital-based case-control...
Read the complete abstract on PubMed