Article
Application of immunocytochemistry and BRAF mutational analysis to direct smears of metastatic melanoma.
Cancer cytopathology - 25 Feb 2012
Hookim Kim, Roh Michael H, Willman Joseph, Placido Jeremiah, Weigelin Helmut C, Fields Kristina L, Pang Judy, Betz Bryan L, Knoepp Stewart M
Abstract excerpt
BACKGROUND: The cytodiagnosis of melanoma in fine-needle aspiration (FNA) specimens can be challenging, often requiring the use of immunocytochemistry. As constitutively activating mutations in the BRAF oncogene are present in at least 40% of melanomas, the use of FNA material to interrogate the BRAF mutational status is likely to increase. Because cell blocks, traditionally used for these studies, can...
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