Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Assessment of V600E mutation of BRAF gene and rate of cell proliferation using fine-needle aspirates from metastatic melanomas.

Anticancer research - 1 Sept 2010

Sviatoha Vitali, Tani Edneia, Ghaderi Mehran, Kleina Regina, Skoog Lambert

Abstract excerpt

BACKGROUND: metastatic melanomas are incurable by systemic treatment and it is therefore of the highest concern to develop new therapeutic regimens. RAF kinases play a key role in the RAS-RAF-MAPK signalling pathway which mediates cellular response to growth signals. An inhibitor of the RAS-RAF-MAPK cascade, sorafenib, has shown promising therapeutic results in treatment of several types of metastatic tumours. It...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Biopsy, Fine-Needle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Immunohistochemistry

Share to Ki-67 Antigen

Share to Melanoma

Share to Proto-Oncogene Proteins B-raf

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

Identifiers

PMID: 20944096

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Assessment of V600E mutation of BRAF gene and rate of cell proliferation using fine-needle aspirates from metastatic melanomas.PMID 20944096Read ↗

Assessment of clinical parameters associated with mutational status in metastatic malignant melanoma: a single-centre investigation of 141 patients.Semantic proximity Read ↗

BRAF V600 mutation detection in melanoma: a comparison of two laboratory testing methods.Semantic proximity Read ↗

[BRAF V600E mutation detection in melanoma patients: clinical and morphological features].Semantic proximity Read ↗

Preponderance of the oncogenic V599E and V599K mutations in B-raf kinase domain is enhanced in melanoma cutaneous/subcutaneous metastases.Semantic proximity Read ↗

Lymph node metastases of melanoma: challenges for BRAF mutation detection.Semantic proximity Read ↗

Incidence of BRAF oncogene mutation and clinical relevance for primary cutaneous melanomas.Semantic proximity Read ↗

BRAF Mutations in Metastatic Malignant MelanomaSemantic proximity Read ↗

Use of cytological samples of metastatic melanoma for ancillary studies.Semantic proximity Read ↗

Distinguishing clinicopathologic features of patients with V600E and V600K BRAF-mutant metastatic melanoma.Semantic proximity Read ↗

High BRAF V600 Mutation Level Associated with Worse Outcome in Metastatic Melanoma Patients Receiving BRAF and MEK Inhibitors.Semantic proximity Read ↗

Preponderance of the oncogenic V599E and V599K mutations in the B-raf kinase domain is enhanced in melanoma lymph node metastases.Semantic proximity Read ↗

Detection of B-RAF and N-RAS mutations in human melanomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.