Article
Male hypogonadism and germ cell loss caused by a mutation in Polo-like kinase 4.
Endocrinology - 1 Oct 2011
Harris Rebecca M, Weiss Jeffrey, Jameson J Larry
Abstract excerpt
The genetic etiologies of male infertility remain largely unknown. To identify genes potentially involved in spermatogenesis and male infertility, we performed genome-wide mutagenesis in mice with N-ethyl-N-nitrosourea and identified a line with dominant hypogonadism and patchy germ cell loss. Genomic mapping and DNA sequence analysis identified a novel heterozygous missense mutation in the kinase domain of...
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