Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease.

Respiratory research - 26 Jul 2011

Kawase Shigeo, Hattori Noboru, Ishikawa Nobuhisa, Horimasu Yasushi, Fujitaka Kazunori, Furonaka Osamu, Isobe Takeshi, Miyoshi Seigo, Hamada Hironobu, Yamane Takashi, Yokoyama Akihito, Kohno Nobuoki

Abstract excerpt

BACKGROUND: A high incidence of interstitial lung disease (ILD) has been reported in patients with advanced non-small cell lung cancer (NSCLC) treated with epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), particularly in Japanese populations. A previous report from our laboratory demonstrated that KL-6 was a useful serum biomarker to assess the severity of drug-induced pneumonitis. Based...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Monitoring
Share to Lung Diseases, Interstitial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mucin-1

Share to Predictive Value of Tests

Share to Protein Kinase Inhibitors

Share to Pulmonary Fibrosis

Share to Severity of Illness Index

Share to Tomography, X-Ray Computed

Source

Open in PubMed Open full text

Identifiers

PMID: 21791074
DOI: 10.1186/1465-9921-12-97
PMCID: PMC3160959

Genes

EGFR
AIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease.PMID 21791074Read ↗

Usefulness of monitoring the circulating Krebs von den Lungen-6 levels to predict the clinical outcome of patients with advanced nonsmall cell lung cancer treated with epidermal growth factor receptor tyrosine kinase inhibitors.Semantic proximity Read ↗

Utility of KL-6/MUC1 in the clinical management of interstitial lung diseases.Semantic proximity Read ↗

Krebs von den Lungen-6 as biomarker of the new progressive fibrotic phenotype of interstitial lung disease.Semantic proximity Read ↗

Molecular and Clinical Features of EGFR-TKI-Associated Lung Injury.Semantic proximity Read ↗

Elevated serum level of sialylated glycoprotein KL-6 predicts a poor prognosis in patients with non-small cell lung cancer treated with gefitinib.Semantic proximity Read ↗

Use of serum KL-6 level for detecting patients with restrictive allograft syndrome after lung transplantation.Semantic proximity Read ↗

EGFR-TKI-Associated Interstitial Pneumonitis in Nivolumab-Treated Patients With Non-Small Cell Lung Cancer.Semantic proximity Read ↗

Potential risk of TNF inhibitors on the progression of interstitial lung disease in patients with rheumatoid arthritisSemantic proximity Read ↗

Interstitial lung disease associated with gefitinib in Japanese patients with EGFR-mutated non-small-cell lung cancer: combined analysis of two Phase III trials (NEJ 002 and WJTOG 3405).Semantic proximity Read ↗

Preexisting interstitial lung disease is inversely correlated to tumor epidermal growth factor receptor mutation in patients with lung adenocarcinoma.Semantic proximity Read ↗

Plasma RANTES, IL-10, and IL-8 levels in non-small-cell lung cancer patients treated with EGFR-TKIs.Semantic proximity Read ↗

Different MUC1 gene polymorphisms in German and Japanese ethnicities affect serum KL-6 levels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.