Article
Usefulness of monitoring the circulating Krebs von den Lungen-6 levels to predict the clinical outcome of patients with advanced nonsmall cell lung cancer treated with epidermal growth factor receptor tyrosine kinase inhibitors.
International journal of cancer - 1 Jun 2008
Ishikawa Nobuhisa, Hattori Noboru, Yokoyama Akihoto, Tanaka Sonosuke, Nishino Ryohei, Yoshioka Koji, Ohshimo Shinichiro, Fujitaka Kazunori, Ohnishi Hiroshi, Hamada Hironobu, Arihiro Koji, Kohno Nobuoki
Abstract excerpt
Krebs von den Lungen-6 (KL-6) is a high molecular weight glycoprotein classified in the category of human MUC1 mucin. KL-6 has been reported to serve as a sensitive marker for interstitial pneumonia; however, recent studies have suggested that it can also be used as a tumor marker as its origin shows. To further elucidate the clinicopathological significance of circulating KL-6 in lung cancer, we monitored the...
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