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Article

CBP/p300 and SIRT1 are involved in transcriptional regulation of S-phase specific histone genes.

PloS one - 1 Jan 2011

He Hongpeng, Yu Fa-Xing, Sun Chi, Luo Yan

Abstract excerpt

BACKGROUND: Histones constitute a type of essential nuclear proteins important for chromatin structure and functions. The expression of major histones is strictly confined to the S phase of a cell cycle and tightly coupled to DNA replication. METHODOLOGY/PRINCIPAL FINDINGS: With RT-qPCR and ChIP assays, we investigated transcriptional regulation of the S-phase specific histone genes and found that the acetylation...

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Share to Acetylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21789216
DOI: 10.1371/journal.pone.0022088
PMCID: PMC3137613

Genes

SIRT1
NPAT

Provenance

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