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Harmony of T cell profile in brain, nasal, spleen, and cervical lymph nodes tissues in Alzheimer's: A systemic disease with local manifestations.

International immunopharmacology - 1 Feb 2021

Pakravan Nafiseh, Abbasi Ardeshir, Basirat Erfan, Dehghan Danial, Heydari Havadaragh Sanaz

Abstract excerpt

The brain has special importance and is known as immune privileged site to and from which trafficking of immune cells is tightly regulated. However, in Alzheimer's disease (AD) the balance of the immune system is disturbed and damages the brain. Given the anatomical and immunological barriers in the brain, we attempted to evaluate if the neuroinflammation occurred in AD is limited to the brain or is expanded to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33383443
DOI: 10.1016/j.intimp.2020.107306

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