Article
Structural analysis of the hot spots in the binding between H1N1 HA and the 2D1 antibody: do mutations of H1N1 from 1918 to 2009 affect much on this binding?
Bioinformatics (Oxford, England) - 15 Sept 2011
Liu Qian, Hoi Steven C H, Su Chinh T T, Li Zhenhua, Kwoh Chee-Keong, Wong Limsoon, Li Jinyan
Abstract excerpt
MOTIVATION: Worldwide and substantial mortality caused by the 2009 H1N1 influenza A has stimulated a new surge of research on H1N1 viruses. An epitope conservation has been learned in the HA1 protein that allows antibodies to cross-neutralize both 1918 and 2009 H1N1. However, few works have thoroughly studied the binding hot spots in those two antigen-antibody interfaces which are responsible for the antibody...
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