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Article

Transfer of repaglinide in the dually perfused human placenta and the role of organic anion transporting polypeptides (OATPs).

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences - 9 Oct 2011

Tertti Kristiina, Petsalo Aleksanteri, Niemi Mikko, Ekblad Ulla, Tolonen Ari, Rönnemaa Tapani, Turpeinen Miia, Heikkinen Tuija, Laine Kari

Abstract excerpt

OBJECTIVES: Our aim was to investigate the placental transfer of repaglinide by ex vivo placental perfusion experiment. In addition, the involvement of the active organic anion transporters (OATP1B1, OATP1B3 and OATP2B1) was studied by assessing the single nucleotide polymorphisms (SNPs) in genes (SLCO1B1, SLCO1B3 and SLCO2B1) encoding OATPs. STUDY DESIGN: Fifteen placentas were obtained after delivery and a 2-h...

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PMID: 21782017
DOI: 10.1016/j.ejps.2011.07.002

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