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Article

miR-15 Family Regulates Postnatal Mitotic Arrest of Cardiomyocytes

22 Jul 2011

Abstract excerpt

RATIONALE: Mammalian cardiomyocytes withdraw from the cell cycle during early postnatal development, which significantly limits the capacity of the adult mammalian heart to regenerate after injury. The regulatory mechanisms that govern cardiomyocyte cell cycle withdrawal and binucleation are poorly understood. OBJECTIVE: Given the potential of microRNAs (miRNAs) to influence large gene networks and modify complex...

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Share to Cardiac electrophysiology and arrhythmias
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PMID: 21778430
DOI: 10.1161/circresaha.111.248880

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