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Article

Association of a synonymous GAT3 polymorphism with antiepileptic drug pharmacoresistance.

Journal of human genetics - 1 Sept 2011

Kim Dong-Uk, Kim Myeong-Kyu, Cho Yong-Won, Kim Yo-Sik, Kim Won-Joo, Lee Min Goo, Kim Sung Eun, Nam Tai-Seung, Cho Ki-Hyun, Kim Young-Ok, Lee Min-Cheol

Abstract excerpt

It would be likely that the genetic variants of the GTA3 gene encoding GAT-3, an astrocytic GABA transporter, may alter gamma-aminobutyric acid (GABA) neurotransmission in the synaptic cleft in the epileptic brain and cause antiepileptic drugs (AEDs) pharmacoresistance. A candidate gene association analysis with fine mapping was performed to dissect the genetic contributions of GAT3 to AEDs pharmacoresistance....

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Identifiers

PMID: 21776001
DOI: 10.1038/jhg.2011.73

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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