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Article

Mutation in the type IB bone morphogenetic protein receptor Alk6b impairs germ-cell differentiation and causes germ-cell tumors in zebrafish.

Proceedings of the National Academy of Sciences of the United States of America - 9 Aug 2011

Neumann Joanie C, Chandler Garvin L, Damoulis Vanessa A, Fustino Nicholas J, Lillard Katherine, Looijenga Leendert, Margraf Linda, Rakheja Dinesh, Amatruda James F

Abstract excerpt

Germ-cell tumors (GCTs), which arise from pluripotent embryonic germ cells, exhibit a wide range of histologic differentiation states with varying clinical behaviors. Although testicular GCT is the most common cancer of young men, the genes controlling the development and differentiation of GCTs remain largely unknown. Through a forward genetic screen, we previously identified a zebrafish mutant line, tgct, which...

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Share to Bone Morphogenetic Protein Receptors, Type I
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasms, Germ Cell and Embryonal

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Identifiers

PMID: 21775673
DOI: 10.1073/pnas.1102311108
PMCID: PMC3156187

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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