Article
Loss of IL-15 receptor α alters the endurance, fatigability, and metabolic characteristics of mouse fast skeletal muscles.
The Journal of clinical investigation - 1 Aug 2011
Pistilli Emidio E, Bogdanovich Sasha, Garton Fleur, Yang Nan, Gulbin Jason P, Conner Jennifer D, Anderson Barbara G, Quinn LeBris S, North Kathryn, Ahima Rexford S, Khurana Tejvir S
Abstract excerpt
IL-15 receptor α (IL-15Rα) is a component of the heterotrimeric plasma membrane receptor for the pleiotropic cytokine IL-15. However, IL-15Rα is not merely an IL-15 receptor subunit, as mice lacking either IL-15 or IL-15Rα have unique phenotypes. IL-15 and IL-15Rα have been implicated in muscle phenotypes, but a role in muscle physiology has not been defined. Here, we have shown that loss of IL-15Rα induces a...
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