Article
Mechanism of host cell MAPK/ERK-2 incorporation into lentivirus particles: characterization of the interaction between MAPK/ERK-2 and proline-rich-domain containing capsid region of structural protein Gag.
Journal of molecular biology - 22 Jul 2011
Gupta Pankaj, Singhal Prabhat K, Rajendrakumar Palakurthy, Padwad Yogendra, Tendulkar Ashish V, Kalyanaraman V S, Schmidt Reinhold E, Srinivasan A, Mahalingam S
Abstract excerpt
The characteristic event that follows infection of a cell by retroviruses Including human immunodeficiency virus (HIV)/ simian immunodeficiency virus (SIV) is the formation of a reverse transcription complex in which viral nucleic acids are synthesized. Nuclear transport of newly synthesized viral DNA requires phosphorylation of proteins in the reverse transcription complex by virion-associated cellular kinases....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.