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Article

Finnish hereditary amyloidosis is caused by a single nucleotide substitution in the gelsolin gene.

FEBS letters - 10 Dec 1990

Maury C P, Kere J, Tolvanen R, de la Chapelle A

Abstract excerpt

The amyloid protein in Finnish hereditary amyloidosis is a fragment of the actin-filament binding region of a variant gelsolin molecule. Here we demonstrate, using polymerase chain reaction and allele-specific oligonucleotide hybridization analyses of genomic DNA, a single base mutation (G654----A654) in the gelsolin gene segment encoding the amyloid protein. The mutation is responsible for the expression of the...

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Identifiers

PMID: 2176164
DOI: 10.1016/0014-5793(90)80510-p

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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