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Article

Gelsolin variant (Asn-187) in familial amyloidosis, Finnish type.

The Biochemical journal - 15 Dec 1990

Ghiso J, Haltia M, Prelli F, Novello J, Frangione B

Abstract excerpt

Familial amyloidosis, Finnish type (FAF), is an inherited form of systemic amyloidosis clinically characterized by cranial neuropathy and lattice corneal dystrophy. We have demonstrated that the protein subunit isolated from amyloid fibrils shows considerable sequence identity with gelsolin, an actin-binding protein. We have purified the amyloid subunit from a second case and further analysed different fractions...

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Identifiers

PMID: 2176481
DOI: 10.1042/bj2720827
PMCID: PMC1149782

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