Article
Extensive telomere repeat arrays in mouse are hypervariable.
Nucleic acids research - 11 Dec 1990
Starling J A, Maule J, Hastie N D, Allshire R C
Abstract excerpt
In this study we have analysed mouse telomeres by Pulsed Field Gel Electrophoresis (PFGE). A number of specific restriction fragments hybridising to a (TTA-GGG)4 probe in the size range 50-150kb can be detected. These fragments are devoid of sites for most restriction enzymes suggesting that they comprise simple repeats; we argue that most of these are likely to be (TTAGGG)n. Each discrete fragment corresponds to...
Topics
- Animals
- Chromosomes
- DNA Probes
- DNA Restriction Enzymes
- Female
- Genetic Variation
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Molecular Weight
- Muridae